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[B] |
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[A] CHIMERA finds a set of transformations $T_1,\ldots,T_k$ allowing to cover the distribution of petients $Y$ by modifying the distribution of control subjects $X$. The $T_i$ are assumed to correspond to different disease effects. Clustering the subjects by disease effect reveals disease subtypes. [B] Voxel-based Morphometry analysis of two Alzheimer's Disease subgroups found by CHIMERA. |
Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers.Brain 2017 140(3):735-747
CHIMERA: Clustering of Heterogeneous Disease Effects via Distribution Matching of Imaging Patterns.IEEE transactions on medical imaging (TMI) 2016 35(2):612-21